Titans vs. Saints prediction, odds, spread, injuries, trends for NFL Week 1

Breaking down a full betting preview for the New Orleans Saints Week 1 matchup against the Tennessee Titans.
Aug 13, 2023; New Orleans, Louisiana, USA; New Orleans Saints quarterback Derek Carr (4) passes to
Aug 13, 2023; New Orleans, Louisiana, USA; New Orleans Saints quarterback Derek Carr (4) passes to / Stephen Lew-USA TODAY Sports

The Tennessee Titans and New Orleans Saints will face-off in an interconference showdown in Week 1 of the 2023 NFL season.

The Saints had a disappointing 2022 season, finishing 7-10 and missing the playoffs. But, hopes are high for them in 2023 as they're set as the betting favorites to win the NFC South with Tom Brady retired from the Buccaneers and Derek Carr as the new QB in New Orleans.

I'm going to dive into everything you need to know to bet on this Week 1 showdown against the Titans, but if you want my best bet for every single game this week, you can find them in my "Road to 272 Bets - Week 1 article here.

Before you place your bets for Week 1 of the NFL season, be sure to sign up at Caesars Sportsbook. For a limited time, you will receive $250 in bonus bets when you place a $50 bet. It doesn't even matter if the bet wins or loses! Just click the link below to take full advantage.

Now, let's dive into the game.

Titans vs. Saints odds, spread, and total

Titans vs. Saints betting trends

  • Titans went 9-7-1 against the spread last season
  • Saints went 7-10 ATS last season
  • The Titans tied for the best UNDER record in NFL last season at 12-5
  • The UNDER went 11-6 in Saints games last season
  • Titans are 2-4 ATS in their last six games against NFC South opponents
  • Saints are 5-1 ATS in their last six games against AFC South opponents

Titans vs. Saints injury reports

Tennessee Titans injury report

  • Josh Whyte - TE - Questionable (ankle)
  • Daniel Brunskill - OT - Questionable (knee)

New Orleans Saints injury report

  • Tre'Quan Smith - WR - Doubtful (groin)
  • Marshon Lattimore - CB - Questionable (knee)
  • Rashid Shaheed - WR - Questionable (groin)
  • Tayson Hill - TE - Questionable (Oblique)

Titans vs. Saints how to watch

  • Date: Sunday, Sept. 10
  • Game Time: 1:00p.m. EST
  • Venue: Caesars Superdome
  • How to Watch (TV): CBS
  • Tennessee Titans Record: 0-0
  • New Orleans Record: 0-0

Titans vs. Saints key players to watch

Tennessee Titans

Treylon Burks: The big name in the receiver room for the Titans is DeAndre Hopkins, but I think Treylon Burks is the more important and pivotal player on this team. He had a solid rookie season, recording 33 catches and 444 yards in 11 games. For the Titans offense to have much hope of success this season, they need Burks to take a significant step forward.

New Orleans Saints

Derek Carr: The Saints went and got the former Raiders quarterback this offseason and now the team's success will come down to how Carr fares in New Orleans. He has some weapons in Michael Thomas and Chris Olave, so hopes are high for the 32-year old. It's going to be fascinating to see how he performs in his Saints debut.

Titans vs. Saints prediction and pick

I truly felt the Saints were much better than their 7-10 record indicated last season. They finished second last in the NFL in average turnover margin at -0.6, and that cost them a handful of wins. If they can slow the turnovers down this season while grabbing a few takeaways of their own, they should be in a solid spot.

Meanwhile, Derrick Henry is not the same running back he used to be, averaging only 4.4 yards per carry last season. If he doesn't get going, I don't think Ryan Tannehill is going to lead them to victory.

I think the Saints win and cover in their Week 1 matchup.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!