Saints vs. Rams prediction, odds, spread, injuries, trends for NFL Week 16

Odds, trends, key players, injuries, and best bet prediction for the NFL Week 16 edition of Thursday Night Football between the New Orleans Saints and Los Angeles Rams.
Dec 17, 2023; New Orleans, Louisiana, USA; New Orleans Saints quarterback Derek Carr (4) gestures
Dec 17, 2023; New Orleans, Louisiana, USA; New Orleans Saints quarterback Derek Carr (4) gestures / Stephen Lew-USA TODAY Sports

The New Orleans Saints will take on the Los Angeles Rams in the NFL Week 16 edition of Thursday Night Football and this NFC showdown will have a massive impact on the playoff picture.

If the season ended today, the Rams would be sitting in the final wild card spot at 7-7, while the Saints would be the first team out, also at 7-7. Let's also remember that the Saints are still very much alive in the hunt for the NFC South, especially considering the Bucs have a tough matchup against the Jaguars set for this week.

In this article, I'm going to break down everything you need to know to bet on this game, including odds, trends, injuries, key players, and my best bet.

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Saints vs. Rams odds, spread, and total

Saints vs. Rams betting trends

  • Saints are 4-10-1 ATS in their last 15 games
  • The UNDER is 16-4 in the Saints' last 20 games
  • Saints are 4-8 ATS in their last 12 games vs. Rams
  • Saints are 0-6 ATS in their last six road games vs. Rams
  • Rams are 4-1 ATS in their last five games
  • The UNDER is 5-1 in the Rams' last is home games
  • Rams are 10-1 ATS in their last 11 games played in December

Saints vs. Rams injury reports

New Orleans Saints injury report

  • Keandre Miller - RB - Questionable
  • Isaiah Foskey - DE - Questionable
  • Ryan Ramczyk - OT - Questionable
  • Chris Olave - WR - Questionable
  • Payton Turner - DE - IR

Los Angeles Rams injury report

  • Tre Tomlinson - CB - Questionable
  • Ahkello Witherspoon - CB - Questionable
  • Rob Havenstein - OT - Questionable
  • Tutu Atwell - WR - Questionable

Saints vs. Rams how to watch

  • Date: Thursday, December 21
  • Game Time: 8:15 p.m. EST
  • Venue: SoFi Stadium
  • How to Watch (TV): PRIME VIDEO
  • New Orleans Saints Record: 7-7
  • Los Angeles Rams Record: 7-7

Saints vs. Rams key players to watch

New Orleans Saints

Alvin Kamara: You don't need me to tell you that Alvin Kamara is the key player in this offense. Not only is he the No. 1 back when it comes to running the football, but he's second on the team in receptions as well with 68, only four fewer than Chris Olave. If Olave isn't able to go again this week, Kamara will once again be the go-to player both on the ground and through the air.

Los Angeles Rams

Kyren Williams: When the Rams No. 1 back is healthy, it transforms this offense. Teams can no longer just focus on stopping the pass when Kyren Williams is in the game, they need to stay honest and keep some players in the box to try to stop the run as well. He's averaging a blistering 5.1 yards per carry on the year.

Saints vs. Rams prediction and pick

There's no denying just how good the Rams have been in recent weeks, but I still think the Saints are an underrated team and may have the defense to slow the Rams offense down. The Saints have one of the best secondaries in the game, allowing the fifth fewest yards per pass attempt (5.7) while also ranking fourth in opponent dropback success rate and third in overall opponent EPA.

You may be surprised to find out the Saints are also eighth in average scoring margin at +3.0 so even in the games they're losing, they're keeping things close. That's why I'm not brave enough to win this game outright and bet on them to upset the Rams, but with the point spread set over the key number of 3.0 at +4, the Saints are the bet to make.

Give me New Orleans and the points on Thursday Night Football.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!