Saints vs 49ers Prediction and Odds for Week 12

New Orleans Saints v San Francisco 49ers
New Orleans Saints v San Francisco 49ers / Brian Bahr/GettyImages

The New Orleans Saints head to San Francisco for a date with the 49ers on Sunday afternoon in the late window of games. NOLA is fresh off their first win in three weeks to move to 4-7 on the year while the Niners are squarely in the playoff picture and hoping to knock off the black and gold.

The Saints have been a very up and down team this year but they've continued to be favored in many of their recent matchups. They are not favored this week and that isn't a surprise to anyone.

Saints vs 49ers Odds Week 12

The Saints enter this game as 8.5-point underdogs with a moneyline of +320. San Francisco's moneyline is -405 and the over/under for points is set at 42.

Saints vs 49ers Prediction Week 12

There's a reason why the 49ers are big time favorites here. They run the ball well, which is something the Saints defense has struggled to stop all season long. The Niners have a good defense, which could give the Saints offense fits, especially if they fall behind early.

San Francisco is a playoff team with a lot on the line in this game. New Orleans is still technically in the playoff picture due to the dumpster fire that is the NFC South but for the most part, they've played like a team that has no business being considered a playoff contender.

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Week 11 was kind to the Saints but they played a team that was somehow worse than they are. That isn't the case this week and I can't pick them to win this game. I'm going with a 34-24 Niners victory with New Orleans scoring some garbage time points late in the action.

Note: Game odds refresh periodically and are subject to change